In addition to the treatment of adult type II diabetes, stimulation of the GLP-1R has also been reported to exert neuroprotective effects in various experimental models of cerebral ischemia, traumatic brain injury, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and many other neurodegenerative diseases [28,29,30,31,32,33,34]. Here, GLP1R is linked to early-onset autosomal dominant Alzheimer disease.