In addition to the treatment of adult type II diabetes, stimulation of the GLP-1R has also been reported to exert neuroprotective effects in various experimental models of cerebral ischemia, traumatic brain injury, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and many other neurodegenerative diseases [28,29,30,31,32,33,34]. This evidence concerns the gene GLP1R and Huntington disease.