The study by Naganuma et al. on single-nucleotide polymorphisms (SNPs) of APE1 suggested that APE1 is a susceptibility gene for cerebral infarction and the G-C-T haplotype (haplotype is a term of SNP and means a group of genes was inherited together from a single parent) of APE1 may be a genetic marker for cerebral infarct in humans [67]. Here, APEX1 is linked to brain infarction.