ACTA1 and nonpapillary renal cell carcinoma: Interactions between tumor cells and the associated stroma influence disease initiation, progression and patient prognosis.35 Based on our self-designed ‘TME PCR Array’ and immunohistochemistry, we found that in the stroma of high Fuhrman grade ccRCC, there are more α-SMA (+) cells compared with low Fuhrman grade ccRCC and these are correlated with progression and survival in ccRCC patients.