In addition, in the molecular function analysis, genes associated with growth factor, chemokine and cytokine activities (GO:0008083, 0008009, 0042379, 0005126, 0005125, molecular function, red) were the prominently enriched (Figure 4h), which suggested that mechanical factors further enhanced the malignant phenotype of tumor cells even when they had already been stimulated with IL-6. This evidence concerns the gene IL6 and neoplasm.