The main findings of this study can be summarized as follows: 1) a significant correlation between the NT-proBNP levels and the burden and complexity of ventricular arrhythmias on the 24-hour Holter ECG monitoring; 2) patients with elevated NT-proBNP levels tend to have a higher number of PVC on the 24-hour Holter ECG monitoring compared to patients with normal NT-proBNP levels; and 3) elevated NT-proBNP levels (>287 pg/ml) are able to predict the presence of frequent and complex ventricular arrhythmias with a high specificity. This evidence concerns the gene NPPB and Ventricular arrhythmia.