LEPR and type 2 diabetes mellitus: T2D rats had significantly higher protein level of the leptin receptor (ratio of intensity: 1.06 ± 0.14 versus 0.54 ± 0.11, P < 0.05) and NR1 receptor (ratio of intensity: 0.43 ± 0.06 versus 0.24 ± 0.03, P < 0.05) in the ARCN (Figure 5).