In the PVN, both leptin receptor and NR1 receptor protein expressions were also significantly increased in the T2D compared to the control rats (ratio of intensity—leptin receptor: 1.23 ± 0.21 versus 0.49 ± 0.11; NR1 receptor: 0.55 ± 0.09 versus 0.20 ± 0.08, P < 0.05). Here, LEPR is linked to type 2 diabetes mellitus.