In our experiments, we found that at 18 hours after CLP, which is considered the acute phase of sepsis in this model [32], pretreatment of rosiglitazone prevented the degradation of NF-κB inhibitor, IκBα, hence repressing NF-κB and subsequently downregulating the proinflammatory cytokines, namely, IL-1β, TNF-α, and IL-6, in the myocardium of septic rats. Here, IL6 is linked to Sepsis.