Pancreatic cancer cells are able to reprogram the TME via secretion of immunosuppressive factors and recruitment of immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs), both of which can suppress the cytotoxicity of CD8+ T-cells and NK cells [92–94]. The gene discussed is CD8A; the disease is familial pancreatic carcinoma.