CLDN4 and neoplasm: Volume-of-interest analysis revealed that uptake of [111In]anti-claudin-4 within claudin-4-overexpressing Panc-1 tumours increased over time, yielding uptake values of 9.5 ± 1.9, 14.7 ± 3.0 and 16.9 ± 4.5 % ID/ml at 24, 48 and 72 h post-injection (p.i.), respectively (Fig. 3b).