We first validated the circRNAs in ROBO1, CDC42BPA, and TNFRSF11A (Fig. 2f and Supplemental S6a) and tested next their differential expression in three WAS and four ADA-SCID samples, compared to four non-affected LCL samples (Fig. 2g). Here, TNFRSF11A is linked to severe combined immunodeficiency.