For example, upregulated BANK1 (p = 2.30 × 10−3, log2-fold change (lfc) = 3.8) or PBXIP1 (p = 3.53 × 10−2, lfc = 2.4) mRNAs in ADA-SCID were associated with impaired B cell receptor-induced calcium mobilization or early blocking of B cell development in the bone marrow (Supplemental Table S4) [79, 80]. The gene discussed is ADA; the disease is severe combined immunodeficiency.