Similarly, it has been described that the adenosinergic-dependent control of anxiety behavior is modified in GPR37 deficient mice (GPR37−/−)2, and that upon deletion of GPR37, adenosine A2A receptors (A2AR) antagonists cannot revert pilocarpine-induced tremor, which is a model for parkinsonism16. The gene discussed is GPR37; the disease is Anxiety.