It is evident that vEnv treatment led to downregulation of cellular HDAC10 and HDAC6 expression (Table 2 and Fig. 6A), and downregulation of HDAC10 by shRNA knock-down significantly enhanced HIV viral infection and/or replication, especially through facilitation of progeny virion infectivity (Fig. 6B,C). The gene discussed is HDAC10; the disease is viral infectious disease.