REST and Alzheimer disease: Thus, we investigated the role of two REST variants (rs3796529 and rs2227902) as modulators of hippocampal volume loss in AD continuum. Contrary to the report from Nho and colleagues10, 11, we observed no effect of the rs3796529 variant on hippocampal volume loss/preservation; instead, the minor allele of rs2227902 was significantly associated with right hippocampal volume reduction in AD.