RENBP and influenza: In support of such difference in immunologic sequela, it has been observed that while continuing peripheral T cell supply contributes to the maintenance of influenza-specific CD8 T cells in the lung41, in-situ T cell proliferation alone, in the absence of peripheral supply, maintains Ag-specific CD8 T cells in an Ag-dependent manner following replication-defective viral vector respiratory mucosal vaccination34.