The accurate differentiation of DLB and AD, however, is particularly important as: (1) the neuropathological lesions are different even if they can be associated3; (2) DLB patients exhibit sensitivity to neuroleptics with worsening of clinical status; and (3) DLB patients have a differing prognosis compared to AD patients4, but have a better response to cholinesterase inhibitors5. The gene discussed is BCHE; the disease is Alzheimer disease.