PRDM1 and lymphoma: In contrast, the disruption of Blimp-1 expression and/or function arrests B-cell differentiation at the preplasmablast stage, and this effect, together with abnormal NF-κb activation, drives the initiation and progression of the activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL), a common subtype of aggressive lymphoma that is typically refractory to current therapies12, 13, 24, 25.