Both Blimp-1 mutants showed similar shortened half-lives relative to that of WT Blimp-1 after ectopic expression in 293T cells, thus verifying that Blimp-1 instability was primarily attributable to these two missense mutations rather than to other potential ABC-DLBCL-associated abnormalities (Fig. 1f). The gene discussed is PRDM1; the disease is diffuse large B-cell lymphoma.