Given that dysfunction of Nav1.6 currents is involved in altered learning, memory, and many neurological and psychiatric brain disorders, such as epilepsy, intellectual disability and pain34, 36, 37, 44, our results suggest that modulating neuronal intrinsic excitability via the CDYL–SCN8A axis could play a key role in both physiological and pathological processes of the brain. This evidence concerns the gene SCN8A and epilepsy.