CCND1 and liver cancer: Consistently, we also observed an increased expression of the Bcl-2, c-Myc, cyclinD1, and MMP7 target genes in primary liver cancer tissue from DEN-treated mice (Fig. 7F, red columns); however, the DEN-stimulated expression of these genes was significantly restrained by the absence of Gab2 (Fig. 7F, green columns).