We then evaluated the tumorigenicity in DEN-evoked WT and Gab2-KO mice and found that there were many tumor nodules on the surface of livers from DEN-treated WT mice (Fig. 2A, upper right); however, there were significantly fewer and smaller tumors in livers from DEN-treated Gab2-KO mice (Fig. 2A, bottom right). The gene discussed is GAB2; the disease is neoplasm.