GAB2 and hepatocellular carcinoma: After incubation for 24 h, some HepG2 cells migrated from the upper surface to the bottom of the chamber (Fig. 3C, top left, purple cells); however, EGFP-Gab2 cells were more migratory than EGFP control cells (Fig. 3C, bottom left), which indicates that Gab2 overexpression promotes HCC cell migration.