In the liver tissue from DEN-treated WT mice without a tumor, the trabecular architecture was almost completely lost and was filled with inflammatory infiltrates and eosin-positive cytoplasmic inclusions (Fig. 6A, middle and bottom left); however, in DEN-treated Gab2-KO mice, paracarcinoma tissue retained the typical trabecular structure, and only little inflammatory infiltrates and fewer/smaller eosinophilic vacuoles of degeneration were present (Fig. 6A, middle and bottom right). The gene discussed is GAB2; the disease is neoplasm.