In a multicenter, prospective, observational study, sTM and protein C were shown to be predictable markers of AKI in critical care settings [16], whereas in another study, sTM and angiopoietin-2 were shown to play important roles in the development of AKI in patients with acute myocardial infarction [17]. The gene discussed is ANGPT2; the disease is myocardial infarction.