Therefore, the objectives of this study were to analyze the expression pattern of ALDH2 and SOD2 genes using available microarray data (GSE65858 and GSE39368) [18] and determine the relationship between the expression level of these two genes and clinical parameters such as alcohol drinking, tobacco smoking, primary site of HNSCC, and human papilloma virus (HPV) state. This evidence concerns the gene ALDH2 and head and neck squamous cell carcinoma.