Histopathological differential diagnosis of IVLBCL mainly includes intravascular anastomotic large T-cell lymphoma [18], intravascular NK/T cell lymphoma [19], the other intravascular lymphoma with B-cell immunophenotype, such as exudative lymphoma, benign atypical intravascular CD30-positive T cell hyperplasia, and intravascular lymphatic tissue cell proliferation. This evidence concerns the gene TNFRSF8 and lymphoma.