BACE1 and Alzheimer disease: To address the issue as to whether BACE1 elevation may occur in spatial relevance with parenchymal Aß deposition, several groups used well-characterized BACE1 antibodies for comparative analysis of BACE1 and Aß immunolabeling in the brains of transgenic AD mouse models, aged humans and clinically diagnosed AD subjects, and aged nonhuman primates [62, 80, 113–116].