Although we demonstrated that ex vivo IFN-γ production ≤ 7.19 IU/mL was an independent predictor for discriminating active and inactive lupus regardless of leukopenia and lymphopenia, there is a possibility that the level of ex vivo IFN-γ production is associated with CD4 T cell numbers. The gene discussed is IFNG; the disease is Decreased total leukocyte count.