Urothelial cancer-associated 1 (UCA1) is first reported to be an oncogenic lncRNA which is highly overexpressed in bladder cancer tissues and promotes bladder cancer cell proliferation by regulating several different downstream targets or pathways, including cAMP response element-binding protein (CREB), chromatin remodeling factor (BRG1), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT) and Wnt pathways [20–25]. Here, CREB1 is linked to urinary bladder carcinoma.