We describe a viral-mediated inducible mouse model of soft tissue sarcoma based on somatic induction and tissue-specific homozygous loss of Trp53 and Pten. Importantly, this model is coupled with Cre-dependent luciferase expression to facilitate in vivo longitudinal, noninvasive bioluminescence imaging (BLI) of gene recombination and tumor formation [14]. This evidence concerns the gene PTEN and soft tissue sarcoma.