In contrast, the vaginal cuff growing metastasis had a higher enrichment score in the Wnt pathway, which has been implicated as a mechanism that impairs recruitment of dendritic cells and prevents T cell infiltration in autochthonous mouse melanoma models via a CXCL9- and CXCL10-dependent mechanism (Spranger et al., 2015, Spranger et al., 2017). This evidence concerns the gene CXCL9 and melanoma.