Previous studies have mainly focused on AS isoforms of individual genes, such as FOXP1, where contradictory findings concerning its prognostic role can partly be explained by smaller and potentially oncogenic FOXP1 isoforms primarily expressed in ABC-type DLBCL.16 Other previously reported genes with AS in DLBCL include a developmentally regulated B-lymphoid phosphatase, PTPRO, regulating G0/G1 arrest17 and a leukocyte homing and hyaluronidase receptor CD44. 18, 19, 20, 21. The gene discussed is CD44; the disease is diffuse large B-cell lymphoma.