It encodes an essential component of the multi-transmembrane γ-secretase complex that is required for the cleavage and activation of integral membrane proteins, including Notch.47 Considering the increasing evidence of the deregulated Notch signaling in cancer progression, γ-secretases playing an important role in Notch activation and that APH1A is critically required for γ-secretase activity, our finding showing that alternative exon usage of APH1A gene has prognostic impact in DLBCL may have therapeutic implications. The gene discussed is APH1A; the disease is cancer.