TP53 and B-cell chronic lymphocytic leukemia: An illustrative case could be the presence of mutations in TP53. Deletions and mutations of this gene have been found to be related to poor prognosis in chronic lymphocytic leukemia,51 multiple myeloma52 and probably in WM.53 However, in our cases this gene appeared mutated at transformation in patient 1 and at progression in patient 2.