CD79B and lymphoma: However, a limited oncogenic potential has been associated with CD79B mutations, since other alterations must occur in order to facilitate the transition to the aggressive lymphoma.46, 47, 48 In conventional WM, CD79B has been found to be mutated in ~10%,17, 20, 25, 26 so the high frequency reported here (3/4 of cases) is intriguing.