An example of these mutations could be the MYD88 L265P, the only one present in all patients and at all times, a mutation with a well established role in both WM and DLBCL.16, 24, 44 However, as it is encountered in over 90% of WM cases at diagnosis, and only a small proportion of them will transform, no inference can be made about its role in transformation. Here, MYD88 is linked to diffuse large B-cell lymphoma.