A confounding factor to in our data is the half-life of M-protein in blood (average 21–25 days for IgG and 7–14 days for IgA), which would cause a time lag between tumor lysis and M-protein decrease; an effect which becomes more pronounce at lower total Ig concentrations.18 Patients with IgA M-proteins and lower M-proteins concentrations pre-ASCT would need a shorter time interval to clear circulating M-protein from blood than IgG M-proteins with high levels pre-ASCT. Here, MYOM2 is linked to neoplasm.