BIRC5 and non-small cell lung carcinoma: In the context of non-small cell lung cancer (NSCLC), the expression of the anti-apoptotic protein survivin is positively correlated with HIF-1α, and promoter activity for survivin expression is impaired by mutating the HIF-1α binding site, thus indicating that hypoxia promotes survival signaling via HIF-1α-survivin axis [47].