Because of the crucial role of PDPK1 downstream PI3‐K/Akt pathway in cancer growth and progression 21, 40 and the reported links of the Akt in regulation of SP1 and DNMT1 expressions in several cancer types in other studies 33, 38, 41, we then assessed the role of Akt signalling in this process. The gene discussed is DNMT1; the disease is cancer.