PDPK1 and neoplasm: In studying the potential mechanisms underlying the hypermethylation of tumour suppressor genes in helicobacter pylori (HP)‐induced gastric carcinoma, one study observed that interaction of PDPK1 and Akt caused to increase in Akt phosphorylation, thereby activating NF‐κB bound to DNMT1 promoter and increasing its expression in gastric carcinoma cells 38.