SP1 and hepatocellular carcinoma: Another report observed that BBR suppressed hepatocellular carcinoma cell growth by upregulating miRNA‐22‐3p and downregulating the expression of SP1, thereby reducing the expressions of its downstream targets, CCND1, (cyclin D1), a oncogenic cell‐cycle‐related protein and BCL2, an apoptosis‐related protein 46.