Moreover, because of the crucial role of PDPK1 downstream PI3‐K/Akt pathway in cancer growth and progression 21, 40 and the reported links of this pathway in the regulation of SP1 and DNMT1 expressions in other studies 33, 38, 41, we also assessed the role of Akt signalling in this study. The gene discussed is PDPK1; the disease is cancer.