Moreover, our results unveiled at least an additive, or perhaps a synergistic effect of combination of BBR and MET in the inhibition of SP1, PDPK1 and DNMT1 expressions, and lung cancer cell growth, implying the potential new role and molecular mechanism in combination with BBR and MET in controlling NSCLC cell growth. The gene discussed is DNMT1; the disease is non-small cell lung carcinoma.