However, less information showed the direct connection of PDPK1 and DNMT1, we believed that this is a first report, which provided the novel insight into the connection between PDPK1 and DNMT1 affected by BBR, and also highlighted the tumour promoter function of PDPK1 and DNMT1 that were involved in the anti‐tumour effect of BBR in this process. Here, DNMT1 is linked to neoplasm.