Therefore, we speculated that TCEAE could improve macrophage infiltration-induced insulin resistance through the activation of PPARα to reduce the production of pro-inflammatory factors in the macrophages, inhibit the generation of pro-inflammatory cytokine IL-6, activate PPARα and increase the expression of adiponectin, which all could lead to the regulation of lipid metabolism and the amelioration of insulin sensitivity. Here, IL6 is linked to Insulin resistance.