Therefore, we speculated that TCEAE could improve macrophage infiltration-induced insulin resistance through the activation of PPARα to reduce the production of pro-inflammatory factors in the macrophages, inhibit the generation of pro-inflammatory cytokine IL-6, activate PPARα and increase the expression of adiponectin, which all could lead to the regulation of lipid metabolism and the amelioration of insulin sensitivity. The gene discussed is PPARA; the disease is Insulin resistance.