Therefore, when a compensatory increased activity of SGLT1 occurs in response to an excessive glucose to be reabsorbed, one would expect an upregulation of this tubular transporter. However, in a genetic model of T1DM (Akita mice) and in response to SGLT2 gene knockout and pharmacological inhibition of SGLT2 in non-diabetic mice, SGLT1 protein expression was found to be reduced. Here, SLC5A1 is linked to type 1 diabetes mellitus.