Activation of p53 and altered Bcl-x/Bax ratio, due to a decrease in anti-apoptotic Bcl-x and increase in pro-apoptotic Bax, was also observed in ventral horns of the lumbar spinal cord of mouse ALS models bearing mutated (G86R) SOD1 gene [66]. This evidence concerns the gene BAX and amyotrophic lateral sclerosis.