Increased p53 immunostaining and mRNA level were detected, already in the preclinical phase, in the retina of rats with myelin basic protein-induced experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of MS that mirrors some aspects of the human disease including neuroinflammation, demyelination and neuronal death, particularly in retinal ganglion cells [67]. This evidence concerns the gene TP53 and myeloid sarcoma.