Although the pathogenesis of eczema remains obscure, the findings show that IL-18 in supernatants of PBMCs of patients with atopic eczema (AE) was significantly higher and that active IL-18 in sera of patients with AE was enhanced at the exacerbation of their disease [3] suggesting that IL-18 may play a role in eczema. Here, IL18 is linked to Eczematoid dermatitis.