Since active sera IL-18 was enhanced at the exacerbation of AE [3], IL-18 is a potent proinflammatory cytokine involved in several chronic skin inflammatory diseases [4–6], and IL-18BP is an endogenous antagonist with high neutralising capacity against IL-18 [14]; our finding emphasizes further the importance of IL-18 and balance between IL-18 and IL-18BP in the pathogenesis of eczema. This evidence concerns the gene IL18BP and Eczematoid dermatitis.