Because we found that combinatorial treatment with green tea polyphenol EGCG and broccoli sprout component SFN led to functionally ERα reactivation in ERα-negative breast cancer cells in vitro, we speculated that this change may benefit further therapeutic strategies through re-sensitizing hormone-resistant ERα(−) breast cancer cells to a hormone antagonist such as TAM. The gene discussed is ESR1; the disease is breast carcinoma.