The ATG5 rs510432 A and rs506027 C allele frequencies in the subgroups of severe sepsis/septic shock were significantly higher than that in the subgroup of mild sepsis, which suggested that rs510432 (−335 G > A) and rs506027 (−769 T > C) within the promoter of ATG5 gene influenced patients predisposition to the progression of sepsis from mild sepsis to severe sepsis/septic shock. Here, ATG5 is linked to Sepsis.