PNPLA3 and steatosis: The same conclusion might be drawn for the presence of steatosis in general because histological steatosis is associated with faster fibrosis progression independent of its aetiology31, and other genetic determinants of hepatic fat content, (e.g., the PNPLA3 I148M and MBOAT7 variation) are associated with fibrosis development patients with CHC8, 10, 32.