We and others have previously shown that the I148M variant of the Patatin-like phospholipase domain-containing 3 (PNPLA3) gene, the major common genetic determinant of hepatic fat content, influences the development of steatosis, and the progression towards advanced fibrosis and hepatocellular carcinoma in patients with CHC8–11. This evidence concerns the gene PNPLA3 and steatosis.