Progression of ALI is associated with dynamic changes in clotting times, thrombin generation, procoagulants (Factor V, Factor VIII, von Willebrand Factor) and anticoagulants (A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats–13, Protein C, Protein S and Antithrombin). Here, PROS1 is linked to acute respiratory distress syndrome.