CASP2 and neuroblastoma: For instance, CASP6 can cleave and activate both CASP2 and CASP8 that are well-known to induce mitochondrial permeabilization54, as well as cleave and inactivate the antioxidant protein deglycase DJ-1, which leads to increase in the production of reactive oxygen species and oxidative stress in neuroblastoma cell lines55.