Aberrant down regulation of DACT1 was previously observed in hepatocellular carcinoma, gastrointestinal stromal tumours and non-small-cell lung cancer (NSCLC)18–20, whereas in colon cancer and squamous cell carcinoma DACT1 was reported to be overexpressed21, 22. This evidence concerns the gene DACT1 and non-small cell lung carcinoma.