Collectively, these results revealed that LCL161 + VSVΔM51 induces T-cell-mediated regression of tumors completely unresponsive to LCL161 + TNFα killing in vitro, which in our hands (Supplementary Figs. 5, 7, and 23) and others16, 17 represents the majority of cancer cell lines tested. The gene discussed is TNF; the disease is cancer.