Kouroku et al. found that abnormal expression and accumulation of polyglutamine Q72 in mouse embryonic carcinoma cells and embryonic fibroblasts led to ER stress and autophagy, and knockdown of PERK-eIF2α could significantly suppress the upregulation of autophagy-related protein Atg12 and LC3-II (Kouroku et al., 2007). Here, EIF2AK3 is linked to embryonal carcinoma.