,101 T cells that expand in pathology and promote development of insulin resistance, atherosclerosis, and hypertension include predominantly IFN-γ-producing Th1 (CD4+) and Tc1 (CD8+) cells, producing IFNγ and TNF, and IL-17 producing Th17 cells (Figures 1 and 3). This evidence concerns the gene CD8A and hypertensive disorder.