ALK (5A4) immunopositivity (IHC score≧1) was evident in 9 (17.6%) of 51 GII, 5 (17.2%) of 29 GIII, and 29 (49.2%) of 52 GIV (GBM) astrocytomas, and the IHC scores were significantly higher in GBM as compared to those of GII and GIII tumors (Fig 1B). This evidence concerns the gene ALK and glioblastoma.