Taken together these results indicate the absence of main differences in the memory status of HBHA-specific CD4+ T-cells among the group studied; conversely, concerning the HBHA-specific CD8+ T-cells, LTBI show mainly a N or CM phenotype, while the TB, HIV-LTBI and HIV-TB groups are characterized by EM or TEMRA phenotypes. This evidence concerns the gene CD8A and tuberculosis.