This study has concluded the occurrence of allele A and SNP A>C in DNA VEGF gene -2578 can predict illness progression in LC to HCC (allele A; OR 2.26) and healthy to CH/LC/HCC (SNP A>C, OR 1.14; allele A, OR 1.65; and SNP A>C, OR 1.41). Here, VEGFA is linked to hepatocellular carcinoma.