NAMPT and Sepsis: Observations that the highest expression of NAMPT in the human body was found in leucocytes [12], that extracellular NAMPT increases the production of inflammatory cytokines (IL-8, IL6, TNFalpha, IL-1ß) [13] and that NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis [14] and activates T cells, B cells and monocytes [13] point to a role for NAMPT in inflammation and inflammatory disease.