Some studies have reported an association between MBL2 polymorphisms and the clinical manifestations of chronic and degenerative diseases, including a positive association between MBL2 variants and vaso-occlusive crises (VOC) in patients with SCA (Collard et al., 2001; Oliveira et al., 2009). Here, MBL2 is linked to autosomal dominant cerebellar ataxia.