In gastric cancer, high CHAC2 expression was correlated with XBP-1s, active caspase-3 or Beclin 1 high expression with a correlation coefficient of 0.305 (P=0.002), 0.607 (P<0.001) and 0.591 (P<0.001), respectively (Supplementary Table S8). Here, BECN1 is linked to gastric cancer.