In colorectal cancer, high CHAC2 expression was also correlated with XBP-1s, active caspase-3 or Beclin 1 high expression with a correlation coefficient of 0.526 (P<0.001), 0.319 (P<0.001) and 0.433 (P<0.001), respectively (Supplementary Table S8). This evidence concerns the gene CASP3 and colorectal cancer.