FGF21 and diabetic cardiomyopathy: Our previous research demonstrated that FGF21 interacts with its receptors to prevent diabetic cardiomyopathy.14 Thus, the mRNA expression of both FGFR1c and β-Klotho receptors, which are reported as two major receptors for FGF21,27 as well as FGFR2, FGFR3, and FGFR4 were examined by qRT-PCR in DOX-treated H9c2 cells and adult cardiomyocytes.