A direct comparison of the TOP10 (plus HDAC10) gene expression among 2D- and 3D-grown cells with tumor tissue samples using our SDHA-normalized real-time PCR data as well as the SDHA-normalized Versteeg microarray data revealed that the gene expression of 3D-grown cells approaches that of tissue material (Figure 4e). The gene discussed is SDHA; the disease is neoplasm.